| | | | | |
| 11-May-23 19:00
Estadio Ka’arendy
Ref:Benítez, D
Lm 1:Cañete
Lm 2:Weiler
|
 | General Caballero JLM
González, Clementino 54' 
González, Clementino 71'
Arce, Sebastián 92'
| 3 - 0 | Guaireña FC
|
| |
| 12-May-23 17:30
Estadio Defensores del Chaco
Ref:Quintana
Lm 1:Aranda
Lm 2:Miranda, G
|
 | Sportivo Ameliano
Samudio, A 1'
Doldán, J 70'
| 2 - 1 | Tacuary
78' Valdez, I
|
| |
| 12-May-23 20:00
Estadio Tigo La Huerta
Ref:López, D
Lm 1:Cardozo
Lm 2:Villagra
|
 | Libertad
Sanabria, L (1999) 33'
Bareiro, A 57'
| 2 - 1 | Trinidense
69' Riveros, M
|
| |
| 13-May-23 17:00
Estadio General Pablo Rojas
Ref:Benitez, C
Lm 1:Candia
Lm 2:Medina, H
|
 | Cerro Porteño
Aquino, C 14' 
Espínola, Alberto 36'
| 2 - 2 | Olimpia
 22' Fernández, H
93' Quintana, H
|
| |
| 14-May-23 17:00
Rogelio Livieres
Ref:López, J
Lm 1:Onieva
Lm 2:Gaona
|
 | Guaraní
Santander, Federico 71'
Moreira, Estivel 84'
| 2 - 2 | Nacional
67' Aguilar, GÁ
78' Ocampos, C
|
| |
| 14-May-23 19:30
Luis Alfonso Giagni
Ref:Benitez, J
Lm 1:Cuevas, J
Lm 2:Saldivar, M
|
 | Resistencia
Villalba, Alexis 95'
| 1 - 1 | Sportivo Luqueño
21' Pérez, Marcelo (2001)
|
| |
|  |
|